Lansoprazole exacerbates pemetrexed-mediated hematological toxicity by competitive inhibition of renal basolateral human organic anion transporter 3
نویسندگان
چکیده
Department of Clinical Pharmacy and Biopharmaceutics, Mie University Graduate School of Medicine (K.I., Y.H., T.I., M.O.), Tsu, Mie 514-8507, Japan Department of Pharmacy, Mie University Hospital (K.I., T.E., Y.M., T.I., M.O.), Tsu, Mie 514-8507, Japan Faculty of Pharmaceutical Sciences, Suzuka University of Medical Science, Suzuka (C.K.), Mie 513-8670, Japan Department of Pulmonary and Critical Care Medicine, Mie University Graduate School of Medicine (H.N., H.F., T.K.), Tsu, Mie 514-8507, Japan This article has not been copyedited and formatted. The final version may differ from this version. DMD Fast Forward. Published on July 27, 2016 as DOI: 10.1124/dmd.116.070722
منابع مشابه
Lansoprazole Exacerbates Pemetrexed-Mediated Hematologic Toxicity by Competitive Inhibition of Renal Basolateral Human Organic Anion Transporter 3.
Pemetrexed, a multitargeted antifolate, is eliminated by tubular secretion via human organic anion transporter 3 (hOAT3). Although proton pump inhibitors (PPIs) are frequently used in cancer patients, the drug interaction between PPIs and pemetrexed remains to be clarified. In this study, we examined the drug interaction between pemetrexed and PPIs in hOAT3-expressing cultured cells, and retros...
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